Cycling through mammalian meiosis: B-type cyclins in oocytes
نویسندگان
چکیده
منابع مشابه
Correction: Mammalian E-type Cyclins Control Chromosome Pairing, Telomere Stability and CDK2 Localization in Male Meiosis
Loss of function of cyclin E1 or E2, important regulators of the mitotic cell cycle, yields viable mice, but E2-deficient males display reduced fertility. To elucidate the role of E-type cyclins during spermatogenesis, we characterized their expression patterns and produced additional deletions of Ccne1 and Ccne2 alleles in the germline, revealing unexpected meiotic functions. While Ccne2 mRNA ...
متن کاملZinc Availability Regulates Exit from Meiosis in Maturing Mammalian Oocytes
Cellular metal ion fluxes are known in alkali and alkaline earth metals but are not well documented in transition metals. Here we describe major changes in the zinc physiology of the mammalian oocyte as it matures and initiates embryonic development. Single-cell elemental analysis of mouse oocytes by synchrotron-based X-ray fluorescence microscopy (XFM) revealed a 50% increase in total zinc con...
متن کاملCohesin in Oocytes—Tough Enough for Mammalian Meiosis?
Sister chromatid cohesion is essential for cell division. During meiosis, it is also required for proper synapsis of pairs of sister chromatids and for chiasma formation and maintenance. Since mammalian oocytes remain arrested in late prophase for a very long period-up to five decades in humans-the preservation of cohesion throughout this period is a formidable challenge. Mouse models with cohe...
متن کاملNegative regulation of TSC1-TSC2 by mammalian D-type cyclins.
The metazoan cell cycle is driven by the timely and composite activities of cyclin-dependent kinases (CDKs). Among these, cyclin D- and cyclin E-dependent kinases phosphorylate the pRb family proteins during G(1) phase of the cell cycle and thereby advance cells beyond the restriction point. Increasing evidence suggests that cyclin D-dependent kinases might affect events other than Rb pathway-m...
متن کاملSpecialization of B - Type Cyclins for Mitosis or Meiosis in S . c e r e a e
The CLBl , CLB2, and CLB3 genes encode Btype cyclins important for mitosis n Saccharomyces cerevisiae, while a fourth Btype cyclin gene, CLB4, has no clear role. The effects of homozygous clb mutations on meiosis were examined. Mutants homozygous for clbl clb3, or for clbl clb4, gave high levels of sporulation, but produced mainly two-spored asci instead of four-spored asci. The cells had compl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2019
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2019.1632139